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Cryopreserved Human Hepatocytes - Prequalified for Key Applications.

High quality - High Viability - Carefully characterized and validated.



Human Hepatocytes from Primacyt

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Our high quality hepatocytes are immediately usable, show high viability and perfectly match your schedules and workflow. It is a convenient solution. Start immediately with your project and do not to wait for liver tissue. Thaw and use hepatocytes where and whenever you need them.

Human Hepatocytes from KaLy-Cell.

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PRIMACYT partners with KaLy-Cell, a French Company based close to Strassbourg at the French-German Border. KaLy-Cell and PRIMACYT jointly serve the market for fresh and cryopreserved hepatocyte cells through their distribution networks. We offer hepatocytes in suspension or plated in a variety of formats.

KaLy-Cell is a leading Company in the field of research of in vitro metabolism, toxicity research and cell therapy. We offer cryopreserved hepatocytes in suspension and plated.


Cryopreserved human hepatocytes undergo the strongest quality checks and are carefully characterized and tested. Besides the parameters as shown below, all deliveries are accompanied by additional photo documentation and other supplemental data.

Human cryopreserved hepatocytes are only for in vitro research use and not for diagnostic or therapeutic procedures.
Human cryopreserved hepatocytes should be stored in liquid nitrogen vapor (-150°C or colder). They should be thawed using Ka-Ly Cells Human CryoHep thawing kit according to the thawing protocol which are shipped with the cryopreserved hepatocytes.

All cryopreserved Human Hepatocytes are packaged to produce an Assured Minimum Yield (AMY), the minimum number of viable cells that you can expect from each vial. The AMY allows for advanced planning and budgeting for your research projects by ensuring that you get the quantity of cells needed for your specific experiment.


Key Application Areas Human Hepatocytes

  • Acute Cytotoxicity Assessment.Cryoheps in suspension are nearly equivalent to plated human hepatocytes (1st to 3rd treatment).
  • Prediction of Hepatic Clearance.Measurement of low metabolic compounds of cryoheps in suspension give better prediction of hepatic clearance than microsomes.
  • Prediction of Fraction Metabolized (fm) close to in vivo.CryoHeps in suspension allow evaluation of donor-specific uptake transporter inhibition and CYP inhibition.
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  • Study Donor dependent Drug Metabolism and Induction.Plateable cryopreserved hepatocytes allow the evaluation of inter-individual variations in drug metabolism enzymes (DMEs) and response to inducers.
  • Prequalified Cryoheps for specific StudiesPlateable cryopreserved hepatocytes can be obtained specically certfied for for studies of metabolism, Induction (qualified for 3 or 2 major CYPs) or certified for transporter studies.
  • Evaluation of Repeat Drug Exposure.Plateable cryopreserved hepatocytes allow the evaluation of chronic exposition to drugs by the measurement of inflammatory signals.
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Take Advantage of fully characterized Human cryopreserved Hepatocytes. Compare Characteristic Parameters on the Fly.


Parameters in Suspension in Suspension Plateable Plateable Plateable
    Transporter Qualified for Metabolism Induction Qualified (3 or 2 major CYPs) Qualyst Transporter Certified
Donor information  
Ethnicity, Gender, Age
 
Cell Biology  
Viability in %
Viable cells/vial
 
Confluency    
 
CYP activities  
7-HCG      
1A1/2      
3A4/5      
2B6      
2C9      
2D6      
 
CYP Specific Activity  
1A2    
3A4/5    
2B6    
2C9    
2D6        
2C8        
 
CYP - Induction Fold  
1A2      
3A4/5      
2B6      
2C9      
 
Biliary canaculi formation      
 
Intrinsic Clearance  
3A4/5        

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