Our high quality hepatocytes are immediately usable, show high viability and perfectly match your schedules and workflow. It is a convenient solution. Start immediately with your project and do not to wait for liver tissue. Thaw and use hepatocytes where and whenever you need them.
PRIMACYT partners with KaLy-Cell, a French Company based close to Strassbourg at the French-German Border. KaLy-Cell and PRIMACYT jointly serve the market for fresh and cryopreserved hepatocyte cells through their distribution networks. We offer hepatocytes in suspension or plated in a variety of formats.
Identify your compounds earlier and win by more efficient and fasters preclinical projects. You can delegate time and intense cell isolations to us as your partner to gain capacity and speed for your of your core R&D activities.
Primary Hepatocytes are best suited to demonstrate major tissue functions, such as ammonia detoxification or drug metabolism. Hepatocytes act as a living biological system. Cryopreserved hepatocytes are extremely well characterised and qualified for key applications.
Not always are fresh hepatocytes available on demand. Hepatocytes, cryopreserved at the day of isolation may be an alternative choice to fresh hepatocytes. Cryoheps allow quick access to specific donor characteristics and desired quantities. Cryopreserved hepatocytes are available extremely well characterized.
Longtime Storage.Cryopreserved hepatocytes can be stored for years at predefined conditions in the vapor phase of liquid nitrogen or in freezers at temperatures below -135°C. Available when you need them, they are an ideal solution for sequential experiments over time.
Create your own donor pool.Combine cryopreserved hepatocytes from your choice of donors. Create and define your preferred hepatic metabolism system in suspensions or on culture plates for extended studies, such as for multiple or gradient toxicity and metabolism experiments.
Use of plated cryopreserved hepatocytesPlated cryopreserved hepatocytes are typically used for studies related to cytochrome P450 induction, drug uptake and efflux transporter activities, toxicity, drug metabolism and systems biology.. Fields of research include metabolic studies, prediction of hepatic clearance, evaluation of acute exposure to drugs, evaluation of cross-individual variations in drug metabolism enzymes and response to inducers.
Human tissue donations come from two major sources: non-transplantable tissues from heart-beating donor, and tissue which is removed during surgical operations and would otherwise be discarded as biological waste. It is vitally important that the public supports the use of human tissue to increase understanding of human disease and develop new and improved treatments.
Human Tissue from KaLy-Cell
KALY-Cell is ethical compliant.Kaly-Cell fully supports the ethical use of human tissues and believes that in order to maintain public confidence and trust, all tissue used must be obtained ethically and with appropriate consent, and be handled and used sensitively and responsibly by researchers. KALY-Cell has the ability by the French Ministry of Research (AC-2008-451) to prepare and store products from human origin for research purposes (CSP articles L 1243-3 and L 1243-4), and the ability by the French Ministry of Research to export human samples (CSP article L 1245-5). KALY-Cell also has the agreement of the French Agency of Biomedicine (CSP article L 1232-3).
KALY-Cell backed by French Government.KaLy-Cell has the ability by the French Ministry of Research (AC-2008-451) to prepare and store products from human origin for research purposes (CSP articles L 1243-3 and L 1243-4), and the ability by the French Ministry of Research to export human samples (CSP article L 1245-5). ALPHA also has the agreement of the French Agency of Biomedicine (CSP article L 1232-3).
All Donor Material tested.KaLy-Cell only accepts tissue from donors who are tested negative for HIV 1 and 2, HTLV, and Hepatitis B and C. However, as a precaution, all human-derived samples should be regarded as a potential biohazard and should be stored, handled and discarded accordingly. Cellular and subcellular fractions are intended for in vitro use only.