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Cryopreserved Cynomolgus Monkey Hepatocytes from PRIMACYT.

PRIMACYT is one of the pioneers in the development of advanced in vitro model systems. We are a leading company in the field of research of human and animal hepatocytes. We offer fresh and cryopreserved animal hepatocytes in suspension and plated.
PRIMACYT is approved by the European Commission as an EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) and serves as member of the laboratory network responsible for the method validation.
Our colleagues are professionals and undergo continuous training in the preparation, isolation and cryopreservation of hepatocytes in general, including related co-products, methods and tools. We are a GLP certified laboratory since 2006.
PRIMACYT is approved by the European Commission as an EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) and serves as member of the laboratory network responsible for the method validation.
Our colleagues are professionals and undergo continuous training in the preparation, isolation and cryopreservation of hepatocytes in general, including related co-products, methods and tools. We are a GLP certified laboratory since 2006.




Info Thawing and Plating Kit


Thawing and Plating Manual


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    Overview
    The liver fulfills many vital processes in mammals. It is the central organ of energy metabolism, responsible for the maintenance of the blood sugar level and the synthesis of plasma proteins under physiological and pathophysiological conditions.

    Hepatocytes are the most prominent cells within the liver. Hepatocytes eliminate toxic substances from the blood. In this biotransformation process transporter proteins (influx and efflux transporter), phase I reactions (cytochrome P450 proteins), phase II reactions (mainly glucuronidation and sulfatation) play a central role.

    Cryopreserved primary hepatocytes are ideally suited for in vitro metabolism and toxicity/detoxification studies before preclinical or clinical tests.

    Monkey hepatocytes are isolated from livers obtained from male or female Cynomolgus and are cryopreserved directly after isolation. Donor demographics stating vaccination status and health status of the animals are available for each animal. Cryopreserved Cynomolgus hepatocytes are used in suspension assays and plated in 2D and 3D cell cultures.
    Our Competencies
    PRIMACYT is one of the pioneers in the development of advanced in vitro model systems. We are a leading company in the field of research of human and animal hepatocytes. We offer fresh and cryopreserved animal hepatocytes in suspension and plated.

    PRIMACYT is approved by the European Commission as an EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) and serves as a member of the laboratory network responsible for the method validation.

    Our colleagues are professionals and undergo continuous training in the preparation, isolation, and cryopreservation of hepatocytes in general, including related co-products, methods, and tools. We are a GLP certified laboratory since 2006.
    Our Offering
    Primacyt offers certified pools of cryopreserved Cynomolgus hepatocytes and hepatocytes from single donors. Pooled hepatocytes are obtained from three individual animal liver perfusions performed in parallel. After quality control, a pool consisting of equal numbers of viable liver cells from each donor is cryopreserved. Also, hepatocytes from individual donors are cryopreserved for reference purposes.

    Each pool and the individual single donors are comprehensively tested for viability, plate-ability, Cytochrome P450/Phase I and Phase II activities to ensure that all donors are represented equally within the pool.

    Cryopreserved hepatocytes from individual donors are also tested for drug transporter activities.
    Cynomolgus Fact Sheet
    View the three page factsheet for Cynomolgus Monkey Hepatocytes

    Additional Product Info
    This info refers to the product data below:
    • Inventory: Number of vials available as of the date of the last update. Availability of vials may have changed since that date by interim orders.
    • Viability: Denotes post-thaw results using the thawing protocol for hepatocytes.
    • To print lot information, please select the print icon at the end of the lists below. For research use only.
    • Not intended for human or animal diagnostic or therapeutic use.

    Lot and Inventory Information - Easy to order via preformatted Email or Shopping Cart.




    Product Code CHCP-I-T. Platable Cryopreserved Cynomolgus Monkey Hepatocytes for Use in Induction and Transporter Studies - Lot and Order Information.
    Information about CYP - Activities, Uptake and Efflux Transporter Activities are contained in the Lot-Info data, if available.
    • Inventory: Number of vials available as of date of last update. Availability of vials may have changed since that date by interim orders.
    • Viability: Denotes post thaw results using the standard thawing protocol.
    • To print lot information, please select print icon at the end of this list.

    2022-01-02

    Lot / Gender

    Inventory (Number of vials)

    Viability (%)

    Recovery (Number of viable cells/vial)

    Total number of cells available

    CYP1A1/1A2 induction x-fold

    EUR per Vial

    CH110922
    female

    7

    94.2 +/- 1.7

    > 6 Mio

    > 42 Mio

    20.6

    775.00

    CH130515-1
    female

    20

    87.5 +/- 0.7

    > 6 Mio

    > 120 Mio

    7.7

    775.00

    CH130806
    male

    20

    82.9 +/- 5.6

    > 6 Mio

    > 120 Mio

    10.3

    775.00

    CH130807
    female

    7

    92.1 +/- 3.8

    > 6 Mio

    > 42 Mio

    6.3

    775.00

    CH140120
    female

    3

    90.3 +/- 4.8

    > 4 Mio

    > 12 Mio

    19.7

    525.00

    CH120717-2A
    male

    6

    88.9 +/- 3.9

    > 4 Mio

    > 24 Mio

    18.6

    525.00

    Q

    Quantity:

    Download Lot Information





    Product Code CHCP-I- Platable Cryopreserved Cynomolgus Monkey Hepatocytes for use in Induction Studies - Lot and Order Information

    • Inventory: Number of vials available as of date of last update. Availability of vials may have changed since that date by interim orders.
    • Viability: Denotes post thaw results using the standard thawing protocol.
    • To print lot information, please select print icon at the end of this list.

    2022-01-03

    Lot
    Gender

    Inventory (Number of vials)

    Viability (%)

    Recovery (Number of viable cells/vial)

    Total number of cells available

    CYP1A1/1A2 induction x-fold

    Price per vial (Euro)

    CH120203-1c
    female

    3

    92.1

    > 4 Mio

    > 12 Mio

    3.0

    500.0

    CH120203-2
    female

    4

    88.2

    > 4 Mio

    > 16 Mio

    10.5

    500.0

    CH130515-2
    female

    1

    94.5 +/- 2.1

    > 6 Mio

    > 6 Mio

    18.6

    750.00

    CH130522
    male

    9

    87.7 +/- 4.5

    > 6 Mio

    > 54 Mio

    4.5

    750.00

    CH141204a
    female

    10

    94.4 +/- 3.9

    > 6 Mio

    > 60 Mio

    17.3

    750.00

    CH141204b
    female

    3

    88.2 +/- 0.0

    > 6 Mio

    > 18 Mio

    22.5

    750.00

    CH180910
    male

    36

    95.5 +/- 0.0

    > 4 Mio

    > 144 Mio

    5.3

    500.00

    CH201109-1
    male

    39

    96.1

    > 6 Mio

    > 234 Mio

    10.2

    750.00

    CH201109-2
    female

    85

    95.4

    > 6 Mio

    > 510 Mio

    18.7

    750.00

    CH210528
    female

    63

    91.3

    > 6 Mio

    > 438 Mio

    8.1

    750.00

    Q

    Quantity:


    Download Lot Information
    Estron-3-Sulfate uptake data are contained in the Lot Info data Sheets.







    Product Code CHCS: Non-characterized Cryopreserved Cynomolgus Hepatocytes for use in Suspension - Lot and Order Information
    • Inventory: Number of vials available as of date of last update. Availability of vials may have changed since that date by interim orders.
    • Viability: Denotes post thaw results using the standard thawing protocol.
    • To print lot information, please select print icon at the end of this list.

    2022-01-02

    Lot
    Gender

    Inventory (Number of vials)

    Viability (%)

    Recovery (Number of viable cells/vial)

    Total number of cells available

    Viability (%) after shaking for 1-2 h at 37°C

    EUR per Vial

    CH110921
    male

    17

    90.4 +/- 2.2

    > 6 Mio

    > 102 Mio

    79

    536.00

    CH120516-2
    female

    11

    91.9 +/- 2.2

    > 4 Mio

    > 44 Mio

    78

    357.00

    CH110802-1
    male

    4

    94.4 +/- 3.9

    > 4 Mio

    > 16 Mio

    76

    357.00

    CH120203-1
    female

    13

    85.7 +/- 1.9

    > 4 Mio

    > 52 Mio

    65

    357.00

    Q

    Quantity:


    Download Lot Information

    CH110802+1 Pending