Stacks Image 1976990

Cryopreserved Cynomolgus Monkey Hepatocytes from PRIMACYT.

PRIMACYT is one of the pioneers in the development of advanced in vitro model systems. We are a leading company in the field of research of human and animal hepatocytes. We offer fresh and cryopreserved animal hepatocytes in suspension and plated.

PRIMACYT is approved by the European Commission as an EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) and serves as member of the laboratory network responsible for the method validation.
Our colleagues are professionals and undergo continuous training in the preparation, isolation and cryopreservation of hepatocytes in general, including related co-products, methods and tools. We are a GLP certified laboratory since 2006.





Info Thawing and Plating Kit


Thawing and Plating Manual

Complete!
Congratulations you have completed all of the steps successfully
    Overview
    The liver fulfills many vital processes in mammals. It is the central organ of energy metabolism, responsible for the maintenance of the blood sugar level and the synthesis of plasma proteins under physiological and pathophysiological conditions.

    Hepatocytes are the most prominent cells within the liver. Hepatocytes eliminate toxic substances from the blood. In this biotransformation process transporter proteins (influx and efflux transporter), phase I reactions (cytochrome P450 proteins), phase II reactions (mainly glucuronidation and sulfatation) play a central role.

    Cryopreserved primary hepatocytes are ideally suited for in vitro metabolism and toxicity/detoxification studies before preclinical or clinical tests.

    Monkey hepatocytes are isolated from livers obtained from male or female Cynomolgus and are cryopreserved directly after isolation. Donor demographics stating vaccination status and health status of the animals are available for each animal. Cryopreserved Cynomolgus hepatocytes are used in suspension assays and plated in 2D and 3D cell cultures.
    Our Competencies
    PRIMACYT is one of the pioneers in the development of advanced in vitro model systems. We are a leading company in the field of research of human and animal hepatocytes. We offer fresh and cryopreserved animal hepatocytes in suspension and plated.

    PRIMACYT is approved by the European Commission as an EU Reference Laboratory for Alternatives to Animal Testing (EURL ECVAM) and serves as a member of the laboratory network responsible for the method validation.

    Our colleagues are professionals and undergo continuous training in the preparation, isolation, and cryopreservation of hepatocytes in general, including related co-products, methods, and tools. We are a GLP certified laboratory since 2006.
    Our Offering
    Primacyt offers certified pools of cryopreserved Cynomolgus hepatocytes and hepatocytes from single donors. Pooled hepatocytes are obtained from three individual animal liver perfusions performed in parallel. After quality control, a pool consisting of equal numbers of viable liver cells from each donor is cryopreserved. Also, hepatocytes from individual donors are cryopreserved for reference purposes.

    Each pool and the individual single donors are comprehensively tested for viability, plate-ability, Cytochrome P450/Phase I and Phase II activities to ensure that all donors are represented equally within the pool.

    Cryopreserved hepatocytes from individual donors are also tested for drug transporter activities.
    Cynomolgus Fact Sheet
    View the three page factsheet for Cynomolgus Monkey Hepatocytes

    Additional Product Info
    This info refers to the product data below:
    • Inventory: Number of vials available as of the date of the last update. Availability of vials may have changed since that date by interim orders.
    • Viability: Denotes post-thaw results using the thawing protocol for hepatocytes.
    • To print lot information, please select the print icon at the end of the lists below. For research use only.
    • Not intended for human or animal diagnostic or therapeutic use.
    Contact us now
    Click on the colored field to ask for more information.

    Ask for cryopreserved Cynomolgus Monkey Hepatocyes

    Download Area (MSDS, Manuals)
    Please click on the buttons below to download MSDS data and the Plating and Thawing Manual.
    Please click on the buttons below to download MSDS data and the Plating and Thawing Manual.






    Lot and Inventory Information - Easy to order via preformatted Email or Shopping Cart.


    Product Code CHCP-I-Pool. Cryopreserved Platable Cynomolgus Hepatocytes - Certified Pool - Order Information.

    • Inventory: Number of vials available as of date of last update. Availability of vials may have changed since that date by interim orders.
    • Viability: Denotes post thaw results using the standard thawing protocol.
    • To print lot information, please select print icon at the end of this list.
    Product Code

    Lot

    Gender

    Inventory (Number of vials)

    Viability (%)

    Recovery (Number of viable cells/vial)

    Total number of cells available

    CYP1A1/1A2 induction x-fold

    Price per vial (Euro)
    CHCP-I-Pool

    CH170704-4

    Male

    53

    95.6 +/- 0.4

    > 4 Mio

    > 212 Mio

    9.2

    819,00
    Q

    Product Code CHCP-I-Pool
    Price per Vial is determined by the number of cells according to the table below:
    4 - 5.9 Mio - EUR 819.00
    6 - 9.9 Mio - EUR 1,219.00

    Quantity:


    Get in Dialog with PRIMACYT and request a Quote by preformatted Email.

    .


    Download Lot Information



    - 20190103


    Product Code CHCP-I-T. Platable Cryopreserved Cynomolgus Monkey Hepatocytes for Use in Induction and Transporter Studies - Lot and Order Information.
    Information about CYP - Activities, Uptake and Efflux Transporter Activities are contained in the Lot-Info data, if available.

    • Inventory: Number of vials available as of date of last update. Availability of vials may have changed since that date by interim orders.
    • Viability: Denotes post thaw results using the standard thawing protocol.
    • To print lot information, please select print icon at the end of this list.

    Product Code

    Lot

    Gender

    Inventory (Number of vials)

    Viability (%)

    Recovery (Number of viable cells/vial)

    Total number of cells available

    CYP1A1/1A2 induction x-fold

    Price per vial (Euro)
    CHCP-I-T

    CH110922

    Female

    17

    94.2 +/- 1.7

    > 6 Mio

    > 102 Mio

    20.6

    558,00
    CHCP-I-T

    CH130515-1

    Female

    21

    87.5 +/- 0.7

    > 6 Mio

    > 126 Mio

    7.7

    558,00
    CHCP-I-T

    CH130806

    Male

    22

    82.9 +/- 5.6

    > 6 Mio

    > 132 Mio

    10.3

    558,00
    CHCP-I-T

    CH130807

    Female

    33

    92.1 +/- 3.8

    > 6 Mio

    > 198 Mio

    6.3

    558,00
    CHCP-I-T

    CH131022-1

    Male

    21

    93.6 +/- 2.5

    > 6 Mio

    > 126 Mio

    26.0

    558,00
    CHCP-I-T

    CH131022-2

    Male

    6

    89.2 +/- 1.6

    > 6 Mio

    > 36 Mio

    45.1

    558,00
    CHCP-I-T

    CH140120

    Female

    3

    90.3 +/- 4.8

    > 4 Mio

    > 12 Mio

    19.7

    372,00
    CHCP-I-T

    CH120717-2A

    Male

    6

    88.9 +/- 3.9

    > 4 Mio

    > 24 Mio

    18.6

    372,00
    Q

    - 20190103


    Product Code CHCP-I-T
    Price per Vial is determined by the number of cells according to the table below:
    2 - 3.9 Mio - EUR 186.00
    4 - 5.9 Mio - EUR 372.00
    6 - 9.9 Mio - EUR 558.00

    Quantity:


    Get in Dialog with PRIMACYT and request a Quote by preformatted Email.

    .


    Download Lot Information





    Product Code CHCP-I- Platable Cryopreserved Cynomolgus Monkey Hepatocytes for use in Induction Studies - Lot and Order Information

    • Inventory: Number of vials available as of date of last update. Availability of vials may have changed since that date by interim orders.
    • Viability: Denotes post thaw results using the standard thawing protocol.
    • To print lot information, please select print icon at the end of this list.
    Product Code

    Lot

    Gender

    Inventory (Number of vials)

    Viability (%)

    Recovery (Number of viable cells/vial)

    Total number of cells available

    CYP1A1/1A2 induction x-fold

    Price per vial (Euro)
    CHCP-I

    CH130515-2

    Female

    1

    94.5 +/- 2.1

    > 6 Mio.

    > 6 Mio

    18.6

    406,00
    CHCP-I

    CH130522

    Male

    15

    87.7 +/- 4.5

    > 6 Mio.

    > 96 Mio

    4.5

    406,00
    CHCP-I

    CH141204a

    Female

    15

    94.4 +/- 3.9

    > 6 Mio.

    > 90 Mio

    17.3

    406,00
    CHCP-I

    CH141204b

    Female

    3

    88.2 +/- 0.0

    > 6 Mio.

    > 18 Mio

    22.5

    406,00
    CHCP-I

    CH141103

    Female

    9

    90.6 +/- 5.3

    > 4 Mio.

    > 36 Mio

    13.6

    271,00
    CHCP-I

    CH180412

    Female

    28

    91.6 +/- 0.0

    > 4 Mio.

    > 112 Mio

    18.4

    271,00
    CHCP-I

    CH180910

    Male

    93

    95.5 +/- 0.0

    > 4 Mio.

    > 372 Mio

    5.3

    271,00
    CHCP-I

    CH190507

    Female

    13

    94.9/- + 0.0

    > 4 Mio.

    > 52 Mio

    7.8

    271,00
    CHCP-I

    CH190123

    Male

    23

    95.7/- + 0.0

    > 4 Mio.

    > 92 Mio

    pending

    n/a
    Q

    - 201910


    Product Code CHCP-I
    Price per Vial is determined by the number of cells according to the table below:
    2 - 3.9 Mio - EUR 133,50
    4 - 5.9 Mio - EUR 271,00
    6 - 9.9 Mio - EUR 406,00

    Quantity:


    Get in Dialog with PRIMACYT and request a Quote by preformatted Email.
    .


    Click on the Lot-Info Hyperlink to see the detailed Lot Information.
    Estron-3-Sulfate uptake data are contained in the Lot Info data Sheets.

    Download Lot Information




    Product Code CHCS: Non-characterized Cryopreserved Cynomolgus Hepatocytes for use in Suspension - Lot and Order Information
    • Inventory: Number of vials available as of date of last update. Availability of vials may have changed since that date by interim orders.
    • Viability: Denotes post thaw results using the standard thawing protocol.
    • To print lot information, please select print icon at the end of this list.

    - 20190130

    Product Code

    Lot

    Gender

    Inventory (Number of vials)

    Viability (%)

    Recovery (Number of viable cells/vial)

    Total number of cells available

    Viability (%) after shaking for 1-2 h at 37°C

    Price per vial (Euro)
    CHCS

    CH110921-1

    Male

    17

    91.9 +/- 2.2

    > 6 Mio

    > 102 Mio

    79

    255,00
    CHCS

    CH120516-2

    Female

    11

    90.4 +/- 2.2

    > 4 Mio

    > 66 Mio

    78

    170,00
    CHCS

    CH110802-1

    Male

    4

    94.4 +/- 3.9

    > 4 Mio

    > 16 Mio

    76

    170,00
    CHCS

    CH120203-1

    Female

    13

    85.7 +/- 1.9

    > 4 Mio

    > 52 Mio

    65

    170,00
    CHCS

    CH121212-2

    Male

    18

    95.7 +/- 4.2

    > 4 Mio

    > 72 Mio

    83

    170,00
    Q

    Product Code CHCS
    Price per Vial is determined by the number of cells according to the table below:
    2 - 3.9 Mio - EUR 85.00
    4 - 5.9 Mio - EUR 170.00
    6 - 9.9 Mio - EUR 255.00

    Quantity:


    Get in Dialog with PRIMACYT and request a Quote by preformatted Email.

    .


    Download Lot Information